About NeuroBionics

NeuroBionics, an MIT neurotechnology spinout, is developing novel implantable devices that interface seamlessly with the human body to treat neurological conditions. Leveraging over a decade of innovation, we have engineered a novel neural interface using microscale, flexible, bioelectronic fibers that can be delivered into the body through minimally invasive endovascular approaches. By making neural interfacing a minimally invasive procedure, we aim to revolutionize deep brain stimulation and broaden access to life-changing neuromodulation therapies to millions of patients.

About the Role:

We are seeking a Senior / Staff Scientist to be our internal scientific expert on how we select and optimize parameters for various therapeutic neuromodulation targets. This is a role for a scientist with deep roots in neurobiology, neuroanatomy, and neurophysiology — someone who understands the neural circuits implicated in disease, the function of specific nerves and targets, and how modulating them produces a therapeutic effect.

You will help shape the scientific direction of the company. Working hand in hand with our strategic marketing lead, you will evaluate candidate indications and neural targets, critically appraise how strong the evidence really is and how well it translates from animal models to humans, and help define which therapeutic areas we pursue. You will support the preclinical validation of our endovascular neuromodulation platform — designing and executing the animal studies that demonstrate the safety and efficacy of our evFiber lead across multiple targets — and build the scientific evidence base that supports our regulatory program.

Alongside the preclinical work, you will take ownership of characterizing the long-term durability and stability of the evFiber lead, with the guidance and direction of an expert external consultant in electrode materials science and electrochemical characterization. Your role there is to execute the work collaboratively, bring a scientific lens to interpreting the results, and translate findings into design improvements.

You will work closely with our CTO, strategic marketing lead, preclinical and clinical teams, and engineering team, and you will be a key contributor to our regulatory submissions and clinical trials.

Job title will be adjusted based on experience.

This is an extraordinary opportunity to join a small, early-stage, VC-backed neurotechnology startup and shape the scientific direction of a cutting-edge implantable technology with the potential to treat millions of patients. This position will be on-site in Somerville, MA. Relocation assistance available

What you’ll do: Duties and responsibilities

As the company’s scientific expert on neuromodulation, you will set the scientific foundation for which targets we pursue and prove out our platform in vivo. Your work spans three connected areas: neuromodulation strategy and scientific diligence, preclinical animal studies, and — with external expert support — characterization of the chronic stability of the evFiber lead.

Neuromodulation Strategy & Scientific Diligence

• Serve as the in-house expert on neuromodulation targets, mechanisms, and what the literature actually supports — bringing deep neurobiology and neurophysiology expertise to every discussion.

• Reason from first principles of neurophysiology: nerve and tract anatomy, the function of specific targets, and how stimulation parameters (frequency, amplitude, pulse width, waveform) map to neural activation and downstream effects on nerves, muscles, and organ systems.

• Build and maintain deep, current knowledge of the neuromodulation landscape — which targets and indications the field is pursuing, the mechanism and physiology behind each, the competitive and clinical-trial activity underway, and where the evidence base is strong versus thin.

• Critically appraise the preclinical and clinical literature for candidate targets, assessing strength of evidence, translatability from animal models to humans, and which stimulation parameters drive which physiologic effects.

• Partner with our strategic marketing lead to evaluate candidate indications and neural targets, and help shape the company’s target roadmap and indication pipeline.

• Track emerging data from ongoing clinical trials and the broader field, and translate those insights into our study design, stimulation paradigms, and strategic priorities.

Preclinical Animal Studies

• Design and implement in vivo animal studies testing the evFiber neuromodulation platform across multiple therapeutic targets (e.g., vagus nerve, peripheral nerves, deep brain targets).

• Develop evidence-based stimulation paradigms by reviewing the neuromodulation literature and define appropriate outcome measures and controls for each target and indication.

• Record, process, and analyze electrophysiology data and other physiologic endpoints (e.g., stimulation-evoked neural activity, cardiovascular responses, autonomic effects) to demonstrate neuromodulation efficacy.

• Perform quantitative data analysis and results visualization on electrophysiology time series and physiologic datasets; synthesize findings into clear scientific reports and presentations.

• Contribute to preclinical study reports and regulatory documentation in support of 510(k) or IDE submissions.

• Stay current with the neuromodulation literature across central and peripheral targets; identify relevant benchmarks and translate insights into study design and stimulation parameters.

Electrode & Lead Chronic Stability Characterization

Working closely with our expert external consultant in electrode materials science and electrochemical characterization, you will:

• Execute electrochemical characterization of the electrodes on the evFiber lead — including impedance spectroscopy, cyclic voltammetry, charge injection capacity, and charge storage capacity measurements — under the guidance of our external consultant.

• Assist in designing and running accelerated aging experiments to evaluate long-term electrode and lead stability; interpret results against FDA/ISO safety standards and Shannon charge injection limits.

• Help identify and characterize failure modes of the current lead design (e.g., moisture ingress, electrode corrosion or oxidation, encapsulation breakdown) and contribute to design improvement efforts.

• Collaborate with the engineering team to prototype and test encapsulation and materials strategies aimed at enhancing the chronic durability and performance of the evFiber lead.

Qualifications:

We seek talented and driven team members who prioritize patient care and will thrive in a dynamic, independent, and results-oriented environment. We are looking for a scientist with deep roots in neuromodulation and in vivo electrophysiology — someone who understands the targets, the tracts, and the physiology, and who has the judgment to tell us which indications are worth pursuing and why. You bring genuine intellectual curiosity about neural interfaces and the ambition to help bring a first-in-class device into the clinic. The ideal candidate has hands-on experience across more than one neuromodulation modality — for example, spanning both central (e.g., deep brain stimulation) and peripheral or autonomic (e.g., vagus nerve stimulation) targets — and is as comfortable designing a stimulation paradigm as analyzing the physiologic data it generates. We seek a creative, independent problem solver who thrives in a fast-paced startup environment and is excited to own a critical piece of our scientific program.

Required Qualifications:

• PhD in Neuroscience, Biomedical Engineering, Electrical Engineering, or a closely related discipline, with a track record of academic excellence.

• Deep command of neurobiology, neuroanatomy, and neurophysiology — the neural circuits and pathways implicated in disease, the function of specific nerves and targets, and how stimulation parameters relate to physiologic effect.

• Command of neuromodulation across multiple targets, ideally spanning both the central nervous system (e.g., deep brain stimulation, cortical stimulation) and the peripheral or autonomic nervous system (e.g., vagus nerve stimulation, sacral neuromodulation).

• Demonstrated ability to critically appraise the preclinical and clinical literature — assessing strength of evidence, translatability from animal models to humans, and the physiologic rationale behind candidate targets.

• Working knowledge of the current neuromodulation therapy landscape and the ability to keep current with emerging data from ongoing clinical trials.

• Hands-on experience designing and executing preclinical animal studies to evaluate the function and efficacy of neuromodulation or neural interfacing devices.

• Experience developing stimulation paradigms and recording stimulation-evoked electrophysiology or downstream physiologic effects of neuromodulation.

• Proficiency in analysis and visualization of electrophysiology time series and physiologic datasets.

• Familiarity with neural interfacing electrode properties and a working understanding of electrochemical characterization — sufficient to execute measurements and interpret results with expert guidance — including working knowledge of safe charge injection limits (Shannon limits) and how electrode geometry relates to stimulation performance.

• Creative, self-directed problem solver, comfortable diving into the scientific literature and translating findings into experimental design and stimulation parameters.

• Comfortable working in a fast-paced startup environment, wearing multiple hats, and stepping up as needed on a small, high-performing team.

Preferred Qualifications:

• Clinical or translational neuromodulation experience, including exposure to indication selection, clinical trial design, or portfolio strategy.

• 3+ years of industry experience working on active implantable neuromodulation devices or neural interfaces (e.g., neurostimulation leads, DBS systems, cochlear implants, peripheral nerve stimulators) under a formal quality management system.

• Experience contributing to regulatory submissions (510(k), IDE, or PMA) or preclinical study reports for regulatory filings.

• Experience in electrochemical characterization of stimulation electrodes — including impedance spectroscopy, cyclic voltammetry, charge injection and charge storage capacity.

• Experience designing or executing accelerated aging experiments for neural interfaces or implantable leads.

• Understanding of materials science and encapsulation strategies for chronically implanted neural interfaces — including failure modes such as moisture ingress, electrode corrosion, and delamination.

• Experience with electrical connector interfaces for active implantable devices (e.g., IS-4, DF-4, ball-seal, or similar standards used in DBS or cardiac rhythm management).

What we offer:

• Mission-driven and collaborative work environment

• Competitive and experience-guided compensation with strong equity package

• 3 weeks flexible vacation + 1.5 weeks company shutdown

• Comprehensive benefits plan including:

  • Health, dental and vision insurance

  • Parental & medical leave

  • Life and long-term disability insurance

  • 401(k)

  • Health & wellness benefit

• Opportunity to work at a fast-growing startup on one of the most impactful problems in neurotechnology and help change patients’ lives

How to Apply:

Interested candidates should submit the following application materials:

• Resume

• A short (~250) cover letter highlighting how your qualifications align with this position

• Contact information for two references

Join us in shaping the future of neurotechnology!